Some breast growth cells require estrogen as well as progesterone female hormones created in the body to develop. At the point when these hormones connect to exceptional proteins called hormone receptors, the growth cells with these receptors develop. breast diseases that have numerous cells with hormone receptors are hormone receptor-positive estrogen receptor-positive ER-positive or potentially progesterone receptor-positive PR-positive. All tumors are checked for hormone receptors. A pathologist decides the receptor status by testing the tumor tissue evacuated amid a biopsy. Most breast diseases are hormone receptor-positive. Hormone treatments are just used to treat hormone receptor-positive breast diseases.